Which of the following is NOT a common manifestation of Type I hypersensitivity?

In Type I hypersensitivity, also known as immediate hypersensitivity, the immune system overreacts to certain allergens, leading to the release of histamines and other inflammatory mediators from mast cells and basophils. This response typically results in symptoms such as urticaria (hives), angioedema (swelling of deeper layers of skin), and anaphylaxis (a severe and life-threatening allergic reaction).

Rheumatic fever, on the other hand, is an autoimmune condition that occurs as a complication of streptococcal throat infection. It is characterized by inflammation of the heart, joints, skin, and brain, often as a delayed type immune response rather than an immediate allergic reaction as seen in Type I hypersensitivity. Therefore, it does not fit within the common manifestations associated with this hypersensitivity type.