Which of the following drugs falls under the class of thiazide diuretics?

Hydrochlorothiazide is a classic example of a thiazide diuretic. Thiazide diuretics work primarily by inhibiting the reabsorption of sodium and chloride in the distal convoluted tubule of the nephron, leading to increased excretion of water and electrolytes, particularly sodium and chloride. This mechanism of action helps in managing conditions such as hypertension and heart failure, as reducing blood volume can decrease blood pressure.

The other drugs listed belong to different classes with distinct mechanisms: Captopril and Enalapril are both angiotensin-converting enzyme (ACE) inhibitors, commonly used to manage hypertension and heart failure by preventing the formation of angiotensin II, leading to vasodilation and reduced blood pressure. Amlodipine is a calcium channel blocker that works by inhibiting calcium influx into vascular smooth muscle and cardiac muscle, resulting in vasodilation and decreased cardiac contractility. Each of these drugs serves different therapeutic purposes and operates through various pharmacological pathways, distinguishing them from thiazide diuretics.