Which of the following agents is NOT commonly associated with coronary vasospasm?

Coronary vasospasm is a condition characterized by temporary constriction of the coronary arteries, which can lead to angina and other cardiac complications. Certain agents are known to trigger or exacerbate this condition due to their pharmacological effects on vascular smooth muscle.

Acetaminophen is not commonly associated with coronary vasospasm because it primarily acts as an analgesic and antipyretic without significant effects on the cardiovascular system. It does not promote vasoconstriction or stimulate the smooth muscle of blood vessels, distinguishing it from other agents.

In contrast, sumatriptan, ergot alkaloids, and cocaine are all known to influence vascular tone and can lead to coronary vasospasm. Sumatriptan is a selective serotonin receptor agonist used in the treatment of migraines and is associated with vasoconstriction of intracranial and coronary vessels. Ergot alkaloids also provoke vasoconstriction by stimulating adrenergic and serotonergic receptors. Cocaine, known for its stimulant effects, can cause vasoconstriction by inhibiting the reuptake of norepinephrine, thus enhancing sympathetic outflow and leading to increased smooth muscle tone in blood vessels.

Therefore, acetaminophen stands out as the agent that does