Which medication is primarily used for the treatment of cholestasia?

Ursodiol is primarily used for the treatment of cholestasis, a condition characterized by impaired bile flow that can result from various liver or biliary disorders. Ursodiol is a naturally occurring bile acid that helps to decrease the production of cholesterol, improves bile flow, and protects the liver cells from damage. It has been effective in treating conditions such as primary biliary cholangitis and intrahepatic cholestasis during pregnancy.

Rifampin is an antibiotic primarily used to treat tuberculosis and certain bacterial infections. Colchicine is mainly used for managing gout and familial Mediterranean fever, while sildenafil is commonly used for treating erectile dysfunction and pulmonary arterial hypertension. None of these other options has a primary role in treating cholestasis or related disorders. Therefore, ursodiol stands out as the appropriate choice for addressing cholestatic conditions.