What is the main consequence of 21 beta hydroxylase deficiency?

The main consequence of 21 beta hydroxylase deficiency is the disruption of adrenal hormone levels. This enzyme plays a critical role in the biosynthesis of corticosteroids in the adrenal glands, specifically in the conversion of progesterone and 17-hydroxyprogesterone into cortisol and aldosterone. When there is a deficiency of 21 beta hydroxylase, this pathway is interrupted, leading to decreased cortisol and aldosterone production.

As a result, levels of the precursor hormones such as progesterone and 17-hydroxyprogesterone accumulate. The lack of cortisol can lead to a variety of symptoms, including an inability to mount an adequate stress response, while the lack of aldosterone can cause issues with sodium retention and potassium excretion. This hormonal imbalance can lead to adrenal crisis and other complications related to hormone deficiencies.

While consequences like an increased stress response or hypertension might occur in different contexts, they do not directly stem from 21 beta hydroxylase deficiency as the primary issue is the improper production and regulation of adrenal hormones. Therefore, the statement regarding disrupted adrenal hormone levels accurately captures the essence of the disorder's physiological impact.