What is a primary effect of testosterone toxicity in females?

Prepare for the COMAT Foundational Biomedical Science Exam with comprehensive questions. Study with flashcards and detailed explanations to boost your exam readiness and understanding.

The primary effect of testosterone toxicity in females is masculinization. This phenomenon occurs because elevated levels of testosterone can lead to the development of male secondary sexual characteristics. Common manifestations of masculinization include hirsutism (excessive hair growth in male-pattern distribution), deepening of the voice, and changes in body composition, such as increased muscle mass and decreased body fat.

The underlying mechanism involves the androgenic effects of testosterone, which can result in alterations to hormone levels and a shift in the balance of estrogen and androgen levels. Such changes can profoundly impact the physical characteristics and biological functions typically associated with female physiology.

In contrast, while increased bone density, menstrual irregularities, and infertility can occur due to hormonal imbalances, they are not the primary effects of testosterone toxicity in the same way that masculinization is. Increased bone density might be seen with certain hormonal changes, but it is generally not a direct or common effect of testosterone toxicity itself in females. Menstrual irregularities and infertility may arise from hormonal disruptions caused by testosterone, but again, these are not the most defining or primary consequences of such toxicity.

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