What is a major characteristic of Prader-Willi Syndrome?

Prader-Willi Syndrome is primarily characterized by a constant sensation of hunger that leads to excessive eating and consequent obesity. This insatiable appetite begins in early childhood and can result in life-threatening complications associated with obesity if left unmanaged. The genetic basis of the disorder involves the loss of function of specific genes on chromosome 15, often inherited from the father, which can contribute to unique physical features and other behavioral aspects.

While cognitive delays and other developmental issues can accompany Prader-Willi Syndrome, the hallmark feature remains the acute appetite and the associated challenges with obesity, which has significant health implications. It’s important to note that the syndrome encompasses a broad spectrum of symptoms, including hormonal imbalances and behavioral issues, but the overwhelming drive to eat is a central and defining aspect of the condition.