What diagnostic marker indicates a positive history of hepatitis B vaccination?

The presence of Anti-HBs (antibodies to Hepatitis B surface antigen) is the diagnostic marker that indicates a positive history of hepatitis B vaccination. After vaccination, the immune system responds by producing these antibodies, which provide immunity against future infections with the hepatitis B virus.

The other markers serve different purposes: HBsAg (Hepatitis B surface antigen) indicates current infection with the hepatitis B virus, while HBeAg is a marker of active viral replication, suggesting a high level of infectivity. Anti-HBc (antibody to Hepatitis B core antigen) may be present in those who have had either an infection or vaccination but is not specific for indicating vaccination status. Therefore, the presence of Anti-HBs is a clear indicator of successful vaccination and immunity against hepatitis B.