What are some of the physical manifestations associated with advanced stages of osteoarthritis?

The choice highlighting joint mice and pronounced subchondral bone sclerosis accurately reflects the physical manifestations associated with advanced stages of osteoarthritis.

In osteoarthritis, as the cartilage that cushions the joints degenerates, various changes occur in the underlying bone and surrounding structures. Joint mice refer to small fragments of cartilage or bone that may become loose and float within the joint space, contributing to pain and mechanical symptoms. Pronounced subchondral bone sclerosis occurs due to increased stress on the bone just beneath the cartilage, leading to increased bone density and hardening in response to the degeneration of cartilage. These features are often observed in advanced osteoarthritis and are indicative of the joint's deteriorating condition.

Other choices highlight symptoms or conditions that are not typical of advanced osteoarthritis. For instance, soft tissue swelling can occur but is generally not as characteristic of the advanced disease as the changes in bone and cartilage. Hypermobility and hyperlaxity of joints are generally not associated with osteoarthritis; instead, they might relate to other conditions such as Ehlers-Danlos syndrome. Similarly, bone tumors and deformities are not direct manifestations of osteoarthritis and may indicate other pathologies.